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The consequence of multiple periods of calorie restriction followed by refeeding, that is, intermittent calorie restriction, has been less well studied. However, several previous studies indicated a protective effect on prevention of spontaneous tumors 77, Further, we have consistently found that intermittent restriction prevents and delays mammary tumor development to a greater extent compared with chronic calorie restriction matched for the same nutrient and calorie intake in two transgenic mouse strains 60—62, Interestingly, it has been reported that women with a history of anorexia nervosa and presumably having bouts of calorie restriction followed by refeeding had a reduced incidence of breast cancer CR reduces experimentally induced tumors of skin 2 and mammary tissue 2 and also decreases tumor burden, while prolonging tumor latency in genetically altered mice 3.

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Epidemiological trials in humans demonstrate an association between limited calorie intake and reduced incidence of breast and colon cancer 14. Edited by malicious earn, 29 June -

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