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Department of Molecular Virology

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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Uncontrolled cell proliferation leads to increased risk of genetic instability.

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Diagnosticul de laborator al infecției cu papilomavirusuri umane HPV. The involvement of epigenetic mechanisms in HPV induced cervical cancer.

The role of HPV16 viral variants in the progression of dysplastic lesions. March, pg 10, Bucharest. E5 HPV16 expression in cervical lesions.

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  7. Олвину, однако, слишком хорошо было известно, что самые страшные опасности этих пещер вовсе не относятся к числу видимых.

Histone lysine demethylases as epigenetic modifiers in HPV-induced cervical neoplasia. Β-catenin gene expression deregulation in pancreatic adenocarcinoma. Department of Molecular Virology Methylation pattern of methylene tetrahydrofolate reductase and small nuclear ribonucleoprotein polypeptide N promoters in oligoasthenospermia: a case-control study.

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